A silver color metal and enamel device 1 1/8 inches (2.86 cm) in height overall consisting of a maroon cross terminating at the top in a trident, surmounted by a silver serpent the tail entwining the vertical bar of the cross, and upon a silver scroll arched at the top of the inscription "SERVICE" and enveloping the base "PEACE OR WAR" in black letters.
Maroon and white (silver) are the colors used for the Army Medical Department. The unit's medical mission is represented by the serpent, an ancient symbol for healing and the cross which alludes to the red cross emblematic of aid in distress. The trident at the top, suggested by the crest of the Mississippi Army National Guard, refers to the Mississippi River.
The distinctive unit insignia was originally approved for the 213th Medical Battalion on 9 October 1967. It was redesignated for the 213th Medical Group on 16 May 1972. The insignia was redesignated for the 213th Medical Brigade on 13 May 1975.